Microspheres prepared with gelatin as the polymer have been found to be highly mucoadhesive and have been used for the controlled release of many drugs. The microspheres appeared long drug retention, stable in gastrointestinal conditions, ph responsive and low toxicity. The microspheres swelled when in contact with moisture and released the drug, fig. The physicochemical and viscoelastic properties of galactomannan are investigated. The freshly excised pieces of intestinal mucosa 2x3 cm from hen were mounted onto glass slides with cyanoacrylate glue. Irbesartan, mucoadhesive microspheres, drug entrapment efficiency, swelling property, in vitro washoff test. This test was done with the help of usp disintegration apparatus in which beaker contained 1. The mechanism of nevirapine release from the mucoadhesive microsphere was found to be anomalous and super caseii. Vishnubhai patel 2, jayvadan patel 3 and ravi patel 3 1 research scholar in jjt university, jhunjhunu, rajasthan, india 2 apmc college of pharmacy, himmatnagar, gujarat, india. Pdf mucoadhesive microspheres as carriers in drug delivery. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies.
The present investigation involves formulation and evaluation of microspheres with rizatriptan benzoate as model drug for prolongation of drug release time. Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources. Guar gum is hydrophilic and swells in cold water, forming viscous colloidal dispersions or sols. Mucoadhesive microspheres which are of 110 00mm in diameter and consisting e ither. Preparation and characterization of mucoadhesive microspheres. Formulation and evaluation of mucoadhesive microspheres of. Mucoadhesivetopenetrating controllable peptosomesin.
Mucoadhesive microspheres phd thesis proposal best essay. All uploads and downloads are deemed secure and files are permanently deleted from the smallpdf servers within an hour. Polyurethene, ureaformaldehyde, pmma, polystyrene 10 15 20 ncy % 0. Rosiglitazone release from these mucoadhesive microspheres was slow and extended over 12 h duration of time depending on the composition of. Merge pdf files combine pdfs in the order you want with the easiest pdf merger available. The pure drug such as clopidogrel was dissolved in 10 ml of water and mixed with the above polymer mixture. Mucoadhesive microspheres a controlled release system designed to increase its residence time in the stomach with contact with the mucosa was achieved through the preparation of mucoadhesive microspheres microspheres are small spherical particles typically 1. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a crosslinking agent. Metronidazole microsphere was developed by ionic gelation method using sodium alginate and calcium chloride. Solid biodegradable microspheres incorporating a drug. The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of acyclovir. The mucoadhesive sustained release of amoxicillin trihydrate is desired because of its short biological halflife. About 100 mg of microspheres were spread onto each wet rinsed tissue specimen and immediately thereafter the. The composition of irbesartan mucoadhesive microspheres shown in table 1.
Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Pdf mucoadhesive polymers and their mode of action. This investigation deals with the intranasal delivery of valsartan, encapsulated in hpmcbased spraydried mucoadhesive microspheres, with an aim to provide rapid absorption and quick onset of action for treating hypertension. Vara lakshmi faculty of pharmaceutical sciences, rajiv gandhi college of pharmacy, rajahmundry, east godavari, andhra pradesh, india. Bioadhesive microspheres for bioavailability enhancement of. The mucoadhesive property of the microspheres was evaluated by in vitro adhesion testing methods called invitro wash off test. Researches are focused to enrich such interaction between the mucous layer and the delivery platform by modifying the system. The objective of the present study is related to the preparation and evaluation of mucoadhesive microspheres of simvastatin by using different polymers like sodium alginate, hpmc k100m, sodium cmc, ethyl cellulose, methyl cellulose. Phase separation is then accomplished by changing the solution conditions by the salt addition, onsolvent addition, addition of the incompatible polymer or change in ph. Wide varieties of polymers such as cationic, anionic, nonionic, thiolated polymers etc have been used to design and develop mucoadhesive drug delivery system. Formulation and invitro evaluation of mucoadhesive.
Microspheres were pale yellow in color, freeflowing, spherical, and porous in outline. The present work is to formulate the mucoadhesive microspheres loaded paracetamol using two different natural gums with an aim to increase the gi retention time, enhance bioavailability over prolonged period of time in the stomach and. Mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. Different methods of formulation and evaluation of mucoadhesivemicrosphere harshad parmar, sunil bakliwal.
Quantitative evaluation of mucoadhesive polymers to compare. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials. If the inline pdf is not rendering correctly, you can download the pdf file here. It was selected as a polymer for preparation of mucoadhesive microspheres because of good mucoadhesive and biodegradable properties. Mucoadhesive drug delivery system copy authorstream. Formulation and evaluation of mucoadhesive microspheres of propranolol hydrochloride for sustained drug delivery akash yadav and dinesh kumar jain department of pharmaceutics, college of pharmacy, indore professional studies ips academy, knowledge village, agrabombay road, rajendra nagar, indore madhya pradesh452012, india. Mucoadhesive microspheres may be an effective strategy for the development of easy, reproducible and cost effective method for safe and effective oral drug therapy. Definition mucoadhesive drug delivery system may be defined as a drug delivery system which utilize property of bioadhesion of certain water soluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time. Formulation of mucoadhesive microspheres of piroxicam.
Alginate microspheres obtained by the spray drying. From the dissolution data of mucoadhesive microspheres by ionic gelation method m1, formulation has shown maximum drug release at 12 h. International journal of engineering science and technology vol. Microspheres constitute an important part of these pdf floating systems for oral controlled release drug delivery floating systems for oral controlled release drug delivery. Mucoadhesive microspheres were prepared by calcium induced ionotropic gelation method. Hpmc k15m and carbopol 940 mediated fabrication of. The aim of present work was to prepare mucoadhesive microspheres containing clarithromycin, an antih. The crystallinity of nevirapine was found to be reduced in prepared mucoadhesive microspheres f12, which were confirmed by xrd studies. This can be achieved by coupling bioadhesion characteristics to microspheres and developing mucoadhesive microspheres. Beads of aceclofenac were produced with different concentrations of polymers 14. Mucoadhesive microspheres for gastroretentive delivery of. Hollow microspheres are used as additives to lower the density of a material.
Mucoadhesive flims leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. An attempt was made to prepare microspheres of rizatriptan benzoate by ionotropic gelation technique, with a view to deliver the drug at sustained controlled manner in gastrointestinal. Our result is supported by the report of chowdary and rao who used the microcapsules of glipizide with a coat consisting of alginate and a mucoadhesive polymer n sodium carboxymethyl cellulose, methyl cellulose, carbopol and hydroxypropyl methyl cellulose. Mucoadhesive microspheres were formulated by emulsification solvent evaporation method using two polymers such as carbopol 974p, hpmc k100m. Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products.
Microspheres adhere to the gastrointestinal mucosa and release the drug for a prolonged period of time. Mucoadhesive and biodegradable polymers undergo selective uptake by the m cells of. The microspheres were fabricated by a solvent evaporation method using carbopol 940 and hpmc k15m as a mucoadhesive polymer along with ethyl cellulose as a filmforming polymer. The numbers of microspheres adhering to the tissue were calculated after 30 min, 1 hr and. Results of preliminary trials indicate that volume of crosslinking agent, time for. Evaluation of irbesartan mucoadhesive microspheres. Microspheres as a promising mucoadhesive drug delivery system. The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Hence, m1 was considered as optimized formulation for mucoadhesive microspheres, and it was followed zero order release. The present study is aimed at formulation of alginate alg microspheres with ranitidine rnt by the spray drying method. Optimization of mucoadhesive microspheres of acyclovir by.
Pdf preparation and invitro evaluation of ranitidine. The mucoadhesive property of the microspheres was evaluated by using 0. Rearrange individual pages or entire files in the desired order. The resulting microspheres were spherical and free flowing. Preparation and invitro evaluation of ranitidine mucoadhesive microspheres for prolonged gastric retention. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery.
Microspheres were discrete, spherical, free flowing and showed a good percentage of drug entrapment efficiency. The rationale of developing mucoadhesive microspheres are that the formulation will be confined on a biological surface for localized drug delivery and the drug will be released close to the site of action with a consequent enhancement of bioavailability. The prepared microspheres showed mucoadhesive properties and controlled release of metformin hydrochloride. When an increase in the polymer concentration retards the drug release more than 12 h. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The sphericity and smoothness of microspheres were confirmed by scanning electron microscopysem. Microspheres can be defined as solid, approximately spherical particles ranging from 1 to.
The cross linking polymer sodium alginate and mucoadhesive polymer were soaked in the water for 24 hours. Preparation of mucoadhesive microspheres the mucoadhesive micrrospheres were prepared by the ionic gelation method. Formulation and evaluation of nevirapine mucoadhesive. Formulation and evaluation of mucoadhesive glipizide films. It is an ideal targeting system with high safty profile. Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration s. Quality by design based fabrication of iron oxide induced. Pesquisaresearch development, optimization and evaluation of alfuzosin hcl mucoadhesive microspheres recebido em 21112012 aceito em 420 hitesh patel 1. Bulk density, tapped density and hausners ratio and carrs index, were determined to assess the flow ability of the prepared microspheres. The interaction was determined by the measurement of mucin adsorbed on the microspheres. It is a cationic polymer polysaccharide jian hwa et al. This study was aimed to develop metronidazole loaded floatingmucoadhesive microsphere for drug release at the mucous layer of upper git. Pdf formulation and evaluation of paracetamol loaded. Formulation of mucoadhesive microspheres of rosiglitazone.
The microspheres exhibited good mucoadhesive property in the in vitro washoff test. Pdf microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Pdf formulation, optimization and evaluation of spray. The aim of th e present study is to provide an overview of various aspects of mucoadhesive microsp various polymers, preparation methodology of microspheres, different methods of. Chitosan, thiolated chitosan, carbopol 71g and methocel k15m were used as mucoadhesive polymers.
Development of floatingmucoadhesive microsphere for site. Buccal route is an attractive route of administration for systemic drug delivery. Mucoadhesive microspheres bioadhesion controlled drug delivery the oral route of drug administration constitutes the most convenient and preferred means of drug delivery to systemic circulation of body but has short gastrointestinal tract. Comparisonof emulsification and ionic gelation method of.
Preparation and in vitro evaluation of mucoadhesive. Galactomannan gum coated mucoadhesive microspheres of. The short residence time of the microspheres at the site of absorption can be. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers. Mucoadhesive microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute. Mucoadhesion is a topic of current interest in the design of drug. Pesquisaresearch development, optimization and evaluation of. The mucoadhesive properties of chitosan microspheres prepared by different method were evaluated by studying the interaction between mucin and microspheres in aqueous solution. Formulation and evaluation of mucoadhesive micropsheres of. Mucoadhesive microspheres form an important part of novel drug delivery system. The core material simvastatin, 2 g was added to the polymer.
The study was aimed to enhance the mucoadhesive potential of eudragit rs 100 and rl 100 using iron oxide. Mucoadhesive microspheres can provide the sustained release of drugs and advantage for pioglitazone hcl in the management of type2 diabetes with a high margin of safety and reduced side effects. One such approach is using microspheres as carriers for drugs. The mucoadhesive microspheres were obtained by incorporating glipizide as model drug in xyloglucan as a mucoadhesive polymer and sodium alginate as a gelforming polymer by the orificeionic. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. The study demonstrates the preparation of mucoadhesive microspheres of metoclopramide using chitosan as a polymer. To change the order of your pdfs, drag and drop the files as you want. Before you combine the files into one pdf file, use merge pdf to draganddrop pages to reorder or to delete them as you like. Morphology by sem of optimized formulation f1 in vitro drug release the microspheres bearing hpmc k4m and atenolol were spherical in shape and in the range of desired particle size. Chitosan is gaining importance in the development of mucoadhesive drug delivery system because of its good biocompatibility, biodegradability and non toxic nature.
Preparation and evaluation of mucoadhesive beadsdiscs of. Microspheres are manufactured in both solid and hollow form. Process for preparation of microcapsules and microspheres 67. Preparation and evaluation of mucoadhesive microspheres of. However, the advantages of microspheres are limited due to their short residence time at site of absorption. An in vitro mucoadhesive test showed that acyclovir mucoadhesive microspheres adhered more strongly to the gastric mucous layer and could retain for an extended period of time. Formulation and evaluation of mucoadhesive glipizide microspheres. The ftir analysis of drug, polymers and the optimized formulation indicated the compatibility of the drug with the polymers. Formulation and evaluation of stomach specific amoxicillinloaded carbopol934p mucoadhesive microspheres for antihelicobacter pylori therapy, j. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug.
Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. Mucoadhesive microspheres containing antihypertensive. Microspheres of eudragit rsrl100, containing cinnarizine, were prepared by emulsification solvent evaporation technique employing 32 full factorial design. Mucoadhesive microsphere carrier systems were made from the biodegradable polymers in sustained drug delivery.
Bioadhesive microspheres for bioavailability enhancement. Formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method k. Sodium bicarbonate was used to incorporate floating property in the microsphere. The slow but complete drug release in the stomach is expected to increase bioavailability of the drug as well as its. Murthy pharmacy department, faculty of technology and engineering, m. In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane. The microspheres were prepared by the wo emulsification solvent evaporation method using mucoadhesive polymers sod. A strong interaction between chitosan microspheres and mucin was detected. The prepared microspheres were collected, dried at room temperature and then weighed. In vitro release of metoclopramide from mucoadhesive microspheres formulations, al a2 a3 a, microspheres was slow and extended and it depended on the processing parameters and polymer to drug ratio.
Formulation and invitro evaluation of mucoadhesive floating. The results of the washoff test indicated that the microspheres had fairly good mucoadhesive properties. Microspheres prepared from admixtures of gelatin and crosslinked chitosan demonstrated some advantage over that prepared from gelatin alone in terms of better controlled release rate of cemetidine. The ftir and dsc confirmed stable character of nevirapine in the drugloaded mucoadhesive microspheres. Glipizide is an oral hypoglycemic drug with short halflife. Microspheres received much attention not only for prolonged release, but also for targeting of drugs. Mucoadhesive microspheres constitute an important part of these particulate drug delivery. The literature survey revealed scanty research on mucoadhesive microspheres of pioglitazone, which were. The present study describes two simultaneous approaches to improve its bioavailability, complexation of rhcl with cyclodextrins, and formulation of mucoadhesive microspheres of the complex using different proportions of carbopol and hpmc. Mucoadhesive microspheres were characterized by their micromeritic properties like bulk density, tapped density, carrs index, hausners ratio and angle of repose 1215.
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